![]() Through her work, Khosravi critically addresses and challenges these historically gendered hierarchies that continue today. Her architectural spaces are inspired by the illuminated manuscripts and miniature paintings of the Persian Safavid dynasty (1501–1736), which portrayed women in subservient or secondary roles. Recurring themes permeate Khosravi’s oeuvre the covering of women’s mouths and eyes, an attempt to police their speech and vision red, gold, and black string birds emblems of confinement and restrictions balls and chains all situated within tight architectural spaces. The Rose Art Museum proudly presents this comprehensive survey, showcasing Khosravi’s immense talent and impactful art.” Her richly symbolic works critically explore women’s oppression and their self-empowerment. “Over the last seven years, she has developed a unique hybrid style that pushes the boundaries between painting and sculpture. “Khosravi’s powerful feminist imagery could not be more relevant as we witness the Iranian regime’s extreme brutality in response to the brave resistance of women and artists chanting ‘Woman, Life, Freedom’ in cities across Iran,” said Ankori. Gannit Ankori, Henry and Lois Foster Director and Chief Curator, Black Rain will trace Khosravi’s development as an artist from her Muslim Ban series, painted on her expired Iranian passports, alongside over a dozen new reliefs and monumental sculptures created especially for the exhibition. 1984) has become known for weaving Persian motifs with surreal iconography, creating ghostly, enigmatic artworks that thematize gender, censorship, power, and cultural transience. June 2023) - Arghavan Khosravi: Black Rain, on view at the Rose Art Museum from August 3 through October 22 in the Lois Foster Wing, is the Iranian artist’s first comprehensive museum survey. Courtesy the arts and Rachel Uffner Gallery, New York. ![]() Purchased with gift from Joseph Nguyen and Tamie Tong, 2021.28. Acrylic and cement on cotton canvas wrapped over shaped wood panel, wood cutout, elastic cord.
0 Comments
![]() With a staggering suite of video options and codecs, the Panasonic Lumix GH6 is one of the most comprehensive consumer video cameras that filmmakers can buy right now. Not only will your footage be slow, but it'll also look fantastic. Its slow-motion credentials are assured, as it's capable of shooting in 4K at up to 120fps, and in Full HD at up to 240fps. The Panasonic Lumix GH6 is only a camera for those who are serious about video – and seriously knowledgeable about it – and if that describes you, then it's one of the most outstanding cameras you can buy. GoPro Subscription explained: what you get, and is it worth it Read our full GoPro Hero 11 Black review for more details Particularly appealing to folks who use multiple social platforms, nothing else can do quite what the 11 Black can. Still, with its new 8:7 sensor, a simplified interface, and enhanced horizon leveling, it's upgraded GoPro's offering in a meaningful way. ![]() The Hero 11 Black might not have wildly improved the line's lowlight performance. You can also grab 27MP stills from 5.3K video. On top of 8:7 video, the Hero 11 Black captures 5.3K resolution video at 60 fps, 4K resolution video at 120 fps, or 2.7K resolution at 240 fps. Able to shoot in 5.3K resolution, 8:7 video at up to 30fps, its footage can be losslessly cropped to create new 4K portrait, landscape, and square clips from a single video. The Hero 11 Black's 8:7 aspect ratio is also a standout highlight for content creators. With best-in-class stabilization, great-looking video in all but dimly-lit and dark scenes, and some fun new modes like light painting, the Hero 11 Black is an excellent addition to the line. The new, almost square sensor is supremely versatile, the camera's software has been simplified successfully, and GoPro's companion app, Quik has also been improved. GoPro membership required to unlock featuresĭespite the Hero 11 Black looking like every other GoPro this side of 2019, with upgraded hardware and software, it's a triumph on all fronts. ![]() Fast frame rates also require a lot of light, as not much is getting to the sensor, so it's worth planning your slow-mo shoot accordingly. Raising the frame rate generally involves lowering the video resolution, which is why you need a decently capable camera in order for the footage to be watchable. However, for real striking shots, you want 120fps or 240fps, and there are cameras that go as high as 960fps, equivalent to a 32x slowing effect. The starting point is 60fps, which can give a half-speed slow-mo effect when played back at 30fps. The maximum frame rates vary from camera to camera, but as a rule of thumb, the higher the better when it comes to slow motion. A huge portion of consumer cameras and even smartphones released today will have some slow-motion capability, with high frame rates for high-resolution video. ![]() This is in part due to social media-the #getwhatyouget hashtag on Instagram has thousands of photos and videos of people reacting as they unfold the paper to discover their tattoo. ![]() “GWYG can be a thrill, as well as a way into for people who don’t have a meaningful design in mind, but have that innate urge to decorate their body.” The Pleasure of Not Choosingĭespite being around for over 15 years, the popularity of Get What You Get has spiked in the last year. “It can serve a therapeutic purpose, doing something that feels kind of wild, and doing it with other people-it can be a real emotional high,” she says. In her experience, there are a few common reasons people seek out GWYG tattoos specifically. Now there’s a new generation of people getting tattooed purely because it’s aesthetically pleasing to them-for whom it’s not so serious.” “It was like, no one could get a tattoo just ‘cause they thought it looked cool. “There was a period of time when people felt pressure to get a tattoo that has sooooo much meaning,” she tells me. It’s since become a feature at many tattoo shops in the US and overseas.Įllis says that, at its core, GWYG is a rejection of the popular notion that a design must have sentimental significance in order to justify having it inked on your skin. Although the Get What You Get (GWYG) method was created by Justin Shaw at Faith Tattoo in Santa Rosa, California around 2004, Ellis believes Idle Hand was the first place to use a gumball machine when they started offering the service in 2009. “There is something magical about letting fate choose your course and just riding that wave,” Holly Ellis, owner and tattooist at Idle Hand Tattoo in San Francisco tells me. I am a wimp (I’ve never ice-skated because I fear if I fall the blade of someone’s skate will slice off my fingers) and I was stone-cold sober when I let fate decide my tattoo, also known as a “Get What You Get.” The Birth of the “Get What You Get” Tattoo Or maybe you assume I’m a cautionary tale, an example of what can happen when you get too drunk or high or lose a bet.īut you would be wrong. I bet in her spare time she enjoys downhill mountain biking and snake charming. What an adrenaline junkie! you might be thinking. A few minutes later, I got it tattooed on the inside of my right forearm. Inside was a folded piece of paper with a small illustration on it. Worthless WASTE of 2 1/2 hours of my trip in Brooklyn and my families time.On a recent Tuesday, I walked into Electric Anvil Tattoo in Brooklyn and turned the dial of an old-school gumball machine. Therefore I opted out of us spending $1400 plus dollars on family tattoos based on the unprofessionalism and unpleasant experience as a 1st time visitor to this establishment. Which he stated,"It would take 3hrs when I selected my 2nd choice. He comes outside and stated, "Their tattoos were about to be next." I asked abt mine and he said, "That mine would need an appointment because it would take 3 hours and they close. My niece asked him what was the wait time. After waiting outside for 1 1/2 hours and observing Vincent walking out the shop to retrieve paper towels from the grocery store. My sister and my niece finally selected their final tattoos to be drafted and agreed on pricing about 30mins later. Again I said let's do it and I would make an appointment on 7/25 to get the initial choice completed (as my flight leaves tomorrow). ![]() I was preliminary quoted $500 then after drawing it up I was quoted $700. After discussing pricing for the art we wanted (Which I had to change my initial Tattoo that I wanted because Vincent told me I would need an appointment to get that particular one done!). ![]() She spoke with Vincent, all was set and we were told to be there by 4pm. I had my sister call and setup an appointment for her, myself and my niece to get tattoos today. The ABSOLUTE WORST EXPERIENCE! If I could give a ZERO it would have been done. Newsom has declared a state of emergency for most of Southern California. The storm's center is expected to weaken further and cross into southern Nevada early Monday. The storm was about 75 miles northeast of Bakersfield, California, with maximum sustained winds of 40 mph at 11 p.m. "The rainfall intensity we are observing is producing SIGNIFICANT flooding issues." "PLEASE.STAY OFF THE ROADS," the NWS in Los Angeles account wrote in a post on X, formerly Twitter. for Los Angeles County and Ventura County.įlash Flood Warning continues for Oxnard CA, Thousand Oaks CA and Simi Valley CA until 3:00 AM PDT /7peTAOC07S- NWS Los Angeles August 21, 2023 and Baja California through Monday.įlash flood warnings remain in effect until at least 3 a.m. The National Weather Service (NWS) has warned people to brace for more flooding, saying "catastrophic and life-threatening" flooding was likely for parts of the southwestern U.S. Hundreds of flights in Los Angeles, San Diego and Las Vegas have been canceled, and the two largest school districts in California canceled classes for Monday. Take nothing for granted," he said during a news briefing in Los Angeles. "That's how quickly this system is moving. Gavin Newsom said the city had been dry when he left on Sunday, but had received "the most significant rainfall over a 60-minute period any time in the history of Palm Springs." ![]() #CAwx /元Z9FOzNwI- Colin McCarthy August 21, 2023Ĭalifornia Gov. One of the most widespread flood events Southern California has seen. All areas highlighted in red are under flash flood warnings. ![]() ******** The Story So Far Part 1 of 6 - Rebirth of the Spider Kingdom ( The events of patch X.0 ) Naxxramas, the Fallen Necropolis Riplash Ruins Doorward Underhalls Terromaw Hold More can be found in the individual dungeon pages. ![]() Here are just some of the maps of the dungeons above. ******** New Spider Kingdom Dungeons and Raidsįewer zones means more dungeons! Find them listed below: Doorward Underhalls Naz'Amun, the Crawling City Vault of the Titans Hanging Tower of Naz'Zuraq Ahn'Vekir, the First City Terrormaw Hold Halls of Flame Halls of Horror Altar of the Old Gods Riplash Ruins Naxxramas - The Fallen Necropolis Raids too! The Necropolis of Nerub Nidhogg's Lair Palace of the Spider Queen Dungeon Maps ******** New Spider Kingdom Zones The Upper Kingdom Shadow Web Caverns Ahn'Saron, the Inner Kingdom * Three new level 95 Elite raids have been unlocked. *Three new level 95 Elite dungeons have been found. Stop the Unspoken, the goddess of the Spider Kingdom, from returning to Azeroth to wreak havoc. Topple the King of Darkness, the ultimate champion of the Old Gods. Thwart the Infinite Dragonflight and their vile scheme to unravel time itself. Explore the secrets of the universe hidden in Algalon's Observatory on the moon. Battle the forces of the Azj'Aqir Resurgence. *New high level quest-chains unlocked throughout Northrend and the Underworld. Explore Azeroth's moon and the secrets it holds. Players can now unlock level 95 Elite status, awarding new bonuses to further empower their characters. * - Level 93 level cap you say?! Yes, because leveling works differently now! Check out the Path of War.Īh made some patches too! Spider Kingdom Patch X.1 - The Shattered Empire * Also feel free to read my various musings on: -New Factions ![]() * New battlegrounds and new arenas are available. * New dungeons and raid instances have been discovered throughout the new Spider Kingdom zones, as well as the newly reshaped Northrend zones. The Northrend content remains a 70-80 leveling experience. The fall of Arthas and the rise of a new Lich King has also brought about a drastic change in the balance of power all across the continent. * The Cataclysm has rent Northrend asunder, altering many of it's regions. Advancing from one level to the next will involve the Path of War leveling system. * New 4th spec for all classes ('cept druids, they already got one, so nyeh.) A fourth zone, the Wound of the World, acts as the center of the Spider Kingdom and a natural barrier separating the leveling zones, but contains no leveling content. These zones are accessed through the Pit of Narjun in Dragonblight. * The Spider Kingdom Revealed: New content zones have been added - The Upper Kingdom, the Shadow Web Caverns, and Ahn'Saron - the Inner Kingdom. This thread is also on the Official WoW Forums - feel free to comment there if you wish: There's a lot of talky, so I'll be trying to break it up over time with some artwork - maps, characters, monsters, and so forth. The second part will involve exploring the depths of Azeroth's underworld, the Spider Kingdom of Azjol-Nerub and beyond. The concept is in two parts - The first centers around the reshaping of Northrend due to the Cataclysm and the death of the previous Lich King, Arthas. It started out as a raid idea, grew into a zone, and has since blossomed out of control into what it is now, which is still growing (Old Gods help me). I've been using WoWpedia's fan fiction section to set up pages related to all the dungeon, storyline, and zone ideas I've come up with, and I'll be organizing them together into what will hopefully become a self-contained fan expansion wiki page. Inspired in equal parts by Cataclysm, Wrath, various wow fan works, and my own not inconsiderable insanity, I've created a fan expansion for World of Warcraft: Long before she dove into the world where the phrase like and subscribe reigns supreme. See photos of Gigi and Nats at the beach a couple years ago. Gigi Gorgeous was a nationally ranked diving champion. She is a popular Internet personality, a successful model and a promising. First she juggles multiple careers with much grace and cool. With more than 2.7 million subscribers to her channel, Gigi is a huge YouTube star. When I finally clicked with it and felt it.it was definitely a lightbulb moment." Gigi Gorgeous (Gregory Allan Lazzarato) is a Canadian YouTuber, model, activist and actress. I think that that's one of the most beautiful things ever. She realized that being pansexual means that you fall "in love with the soul of somebody. Gigi doesn't regret her previous coming out videos as they are part of who she is as a person. I mean, I understood it for them, but could never see myself as pansexual," she said. Co-authored with one of her best friends, RuPaul’s Drag Race alum Gottmik, The T. It never really stuck with me, I never really got it. Gigi Gorgeous is paying it forward with her new book by sharing what she’s learned over the past 31 years. ![]() I'd heard that term before, I knew a few friends that identified as that. Explaining my full lip injection experienceHope you enjoy and if you have any questions Ill try my best to answer themFor more videos, subscribe: http://. I just want to let everybody know that I am pansexual. Nats has 164,000 followers on her Instagram natsgetty, and often posts photos with their wife Gigi Gorgeous who is a popular YouTuber and social media personality with almost three million. I fell in love with the person that he is. The 16-minute clip shares never-before-seen images and footage from Nat’s top surgery, which. Done Already A few more words can help others decide if its worth watching. Nats Getty: 5 Things To Know About Gigi Gorgeous’s Partner Who Has Come Out As Transgender. "Over the years, I've realized that I didn't fall in love with Nats because of his gender. Want to submit changes to your review before closing Submit Discard changes. It's always been there, this girl has always been inside of me, but it took this stage of my life really to open up, and I'm ready to share this with you guys." "Yes I am transgender, but at the end of the day I am me and at the end of the day, you are you," de Jager said.Gigi continued, "It was actually through my husband Nats that this kind of was unlocked inside of me. Gorgeous came out as transgender in 2013, later documenting her transition for the world to see. ![]() The beauty influencer - known for her "power of makeup" tutorials - said that her mother was her biggest support overall during her transition and was overwhelmingly positive when de Jager was coming out.ĭe Jager emphasized that she wants her followers to not solely focus on her gender identity and to continue to see her as a whole person. Gigi Gorgeous has amassed a following of 2.9 million since starting her makeup channel in 2008. Nikkie de Jager, better known as NikkieTutorials to her followers, announced she is a transgender woman for the first time to her 12 million YouTube subscribers on Tuesday.ĭe Jager, a Dutch YouTuber, told her subscribers that after receiving blackmail threats she made the decision to "start the year off with the truth." Throughout the video, de Jager shared her transition story, saying she fully transitioned by the time she was 19 years old. Photo by Jamie McCarthy/Getty Images for Marc Jacobs Nikkie de Jager attends the Marc Jacobs Spring 2020 Runway Show at Park Avenue Armory on Septemin New York City. before being thrust into the spotlight with her decision to embrace her true self. ![]() ![]() Account icon An icon in the shape of a person's head and shoulders. Gigi Gorgeous put on a sizzling display on Thursday night as she supported husband Nats Getty at his art salon benefitting the non-profit The Art of Elysium. Producer: This Is Everything: Gigi Gorgeous. ![]() Knowledge and the realistic ramifications of Mercy's memory loss – weįound ourselves asking one main question: What are we if not the sum of our ![]() ![]() Period, as well as Mercy's amnesia, was extensive. In essence, she has lost an entire lifetime and can't do anythingĪt the end of the American Civil War and the research we did about the time Is a blank slate the day she wakes from a coma is the first day she can Our main character has been erased – including her own name. In fact, everything and anything that is personal to Of calling up special memories – because due to a head injury, she has no MERCY, I co-authored with Michael Landon, Jr. It was in that moment that I had a rush of sympathy for Mercy, the protagonist I can replay those special events time and time again whenever the spirit moves me. While my husband and I watched them exchange vows, Iįiled away another memory to call up at will – taking it for granted that ![]() Moments at Christmas andĮaster Egg hunts, skinned knees, failures and triumphs and the day he called to To walk, ride a bike – first day of school. Years of memories of my son rush through my head. Makeshift aisle of wildflowers and we all had time to glance from his beamingįace to hers – which was radiantly happy. His bride, on her father's arm, had a long walk down their Was there to see my only son marry the love of his life under a simple arch madeįrom birch trees. I create original works in acrylic and provide prints of original works.Ĭolor-driven, whimsical paintings and accessories.I stood in the middle of sixty acres this past weekend, in a meadow surroundedīy pine trees and beautiful mountains. Oil, acrylic and resin paintings, as well as prints Printed goods, apparel, paper goods, custom graphics, fine art, accessoriesįound Ephemera Art creates thoughtful, upcycled mixed media work using only found papers and objects, giving the otherwise discarded a new life in a new context.Ĭhalk Art, Hand-lettering, Murals & SignageĬontemporary abstract paintings, home decor & and apparel that envoke smiles and good thoughts Hammered bottlecap pendants, recycled metal art, Zendala drawings, Tie-dye art, Rock art Mixed media painting, printmaking, watercolors Metalsmithing and handmade wire wrapped jewelry Handcrafted Adornments for the Warrior Within Oil and Acrylic Paintings of everyday settings and situations Whidbey Island, Washington, United States Sculpture & gifts made of wood and a touch of chaos.Ībstract and landscape paintings and photography Original paintings, prints and cards from this. One-of-a-kind necklaces, bracelets & earrings created from a variety of gemstones, gold, silver, CZ, wood, leather and moreĪmelia Sherritt creates unique collage art out of 100% upcycled wine foil capsules. Multi media, abstract floral and landscape paintings Reclaimed Art to include paintings, wooden toys and sculptures.įine art Photography, Resin Art, Acrylic Pouring Performance & Circus Arts, Graphic Design, Illustration, Oil Painting, 3D Design, Digital Photo Manipulations and just about anything else.Īcrylic painting, stationary and coloring booksĬeramic and mixed media figurative sculpture Mixed media paintings, assemblages, arashi shibori silk scarvesįine art drone photos from Austin, Texas. Handmade sterling silver & gemstone jewelry Visionary, Abstract, Geometric, Vibrant, Playful, Visual Works in oil, acrylic and mixed media painting, block print, fabric, clothing.ĢD wall constructions, sculpture, installation, public artĪbstract watermedia collage influenced by Midcentury Modern & Japanese art. I work in encaustic medium to create work that speaks to remembered moments through selected bits and pieces from the natural world, usually with a reference to trees. Sculpture, Photography, Public Art, Installation ArtĪcrylic, Oil and Resin Paintings, Landscape, Architectural and Abstract The Particle Track Series are highly colorful, energetic, lively abstractions based on the imagery of high speed sub-atomic particle collisions gathered at the high energy particle physics facilities. Multi-media painter, bringing color and whimsy to collectors! ![]() Horton should not have been injured that evening, and we hope this case will inspire the County to improve deputies’ training on how to manage mass gatherings so that all citizens’ rights are protected,” Trimble said. “We are grateful the County has acknowledged that Ms. Horton’s attorney, Kimberly Trimble, said in a statement that Horton and her children were exercising their Constitutional rights by attending the protest. Never did it occur to me that I would be injured by law enforcement.” Deputies were at the scene to assist La Mesa police. Horton was shot with the beanbag as a caravan of four county Sheriff’s Department vehicles passed through the intersection of University Avenue and Spring Street about 9 p.m., her attorney said. ![]() “We were bonafide supporting the protests and the cause.” “This wasn’t about social media,” she said. She said she told her children not to take pictures to post online. ![]() French toast not bad either both you can have have and enjoy.Horton said her biggest concerns about going to the protest were getting separated from her children in a large crowd or getting a wallet stolen - not getting shot. The eggs benedict was good but again just had them at another competitor last week and those were out of this world with waguy beef so definitely not memorable at the end. again they were very busy and with the queue forming outside was definitely downgrading the experience. Manager was very switched on and observed lapses and tried to fix but recommend a review of the service. Service below par and from what I saw from other tables similar experience have to ask for the basic staff and more than once which again I don’t find acceptable for that price range. Coffee was good and tried both the latte and the cappuccino definitely recommended. Had to sit outside definitely not a luxurious experience wooden tables run downlooking something out of a cheap place which they are definitely not. Obviously they are very successful with local patrons It is not an expat hangout if you are looking for that sort of thing definitely head off to bangsar or klcc. Read so much about it and decided to visit. I heard that they are planning to move - but the last time I checked, they are still at the same address hence this post. Looked like a big mess when served, and especially when I poked the egg for the yellow yolk to ooze out. ◾Chooked - sesame pan fried marinated chicken with corn kennels and crispy kale on a bed of potato pancake, topped with a poached egg and drizzled with hollandaise and sriracha sauce. The hollandaise sauce was on-point and the colour of the salmon made the whole plate looked happy. ◾The Atlantic - In-house cured salmon served with ikura, Australian baby spinach, sauteed mushrooms, fluffy french toast, drizzled with hollandaise sauce and served with two poached eggs. The sonny somehow managed to whack all of these. ◾Rendang Burgembira - sesame burger bun with Rendang sous vide chicken thigh, fried egg, lettuce, tomato and traditional tempeh. This platter is something like a big breakfast, and could easily fill 2 hungry tummies. You'd notice that I didn't order beef options here because I don't eat beef. ◾Super Awesome Fry Up - sunny side up eggs, chicken sausage and turkey ham, assembled with classic baked beans, hash brown, sauteed mushrooms, multigrain & sourdough toasts. just limited to the usual big breakfast or egg Benedict's, they offer beyond the usual breakfast dishes and incorporate many creative creations to keep people coming back again and again. Opened for more than 10 years, they have been serving plates and plates of breakfast to early risers including yours truly. If you love a hearty English style breakfast, the name Red Beanbag shouldn't be a stranger to you. Restaurants with Outdoor Seating in Kuala Lumpur. ![]()
![]() This helps make it more visible to the technician under the typical light Water is also avoided in capsule staining because it would dislodge the capsule.Ī drop of serum may be used on the smear to enhance the size of the capsule. Unlike endospores, capsules are more delicate.įor this reason, using heat during the staining process should be avoided given The cell and a light violet color of the capsule. Here, one will see a dark violet color of Ultimately results in the diffusion of a stain towards the outer surface of theĪfter the slide is air dried, it becomes possible to observe the stain (copper sulfate) for the purposes of creating an ionic difference that Here, the smear/sample is treated with a hypertonic solution This is a positive staining method used inĬapsule staining. Microscope stage and observe using oil immersion With Anthony’s stain method, the primary stainĪnd at an angle, spread the drop and sample to form a thin film Gives a more even background and spreads more easily. * Nigrosin is recommended to India ink because it Taken the crystal violet dye while the capsule will be clear against a dark Will be dark as a result of India ink, bacteria cells will be purple having When viewed under the microscope, the background On the other hand, crystal violet is used for number of reasons including: Nature, India ink (or Congo red, nigrosin) stains the background dark. This is a negative staining technique that isĮssentially used to identify the presence of capsules. However, some of the other stains that can also be used include: India ink is often used as the negative stain. Spread out the drop into a film to have a thin layer of the smear-ink mixtureĬrystal violet for a minute and then tilt the slide to drain excess dye Glass slide and having laid it at an angle on one end of the first slide, Obtain a sample and place it onto the slide and mix it with the drop of India Two of the most commonly used methods used in It becomes necessary to stain the background using an acidic stain while the It's worth noting that for most part, capsules are non-ionic.Īcidic and basic stains will often fail to adhere on to them. Which involves the use of two stains primary stain and the counterstain. Some of the organisms that are likely to have aĬapsule stain is a type of differential stain Some of the other significance of a capsule This is achieved due to the fact that the capsule is very smooth and has a negative charge that prevents attachments/adherence. For some bacteria, capsules are very important in that they are a major virulence factor.Īs such, they protect the bacteria from phagocytic actions of such cells as neutrophils allowing the bacteria to thrive. ![]() They may also be composed of a number of other materials such as poly-D-glutamic acid. Typically, a capsule is composed of capsular polysaccharides (CPS) which are polysaccharides. Monochrome Staining – Principle, Procedure and Result | Biology Ideas ![]() Our research may provide valuable insights into the mechanisms underlying human embryonic development and developmental disorders. Recently, we found that Tfcp2l1-mediated fatty acid oxidation plays a critical role in maintaining ESC survival during metabolic stress (Yan et al., EMBO Reports, 2021). Currently, we are studying the metabolic stress responses of ESCs. Our research has shown that p53 plays an essential role in regulating ESC differentiation after DNA damage by down-regulating the transcription of many ES cell critical genes (Li et al., Cell Stem Cell, 2015 Zhang et al., Cell Cycle, 2013 Li et al., Molecular Cell, 2012 Lee et al., PNAS, 2010). To address this question, we have studied how the tumor suppressor protein p53 regulates the DNA damage responses of ESCs. Despite this importance, the mechanisms by which ESCs maintain genome stability in response to DNA damage insults are poorly understood. As ESCs have the potential to differentiate into many different cell types and are a promising source for cell therapy, maintaining genomic stability and homeostasis is crucial for proper lineage choice. Interest 1: Transcriptional and epigenetic stress responses of embryonic stem cells. By conducting basic research on these transcription factors, we aim to generate novel insights into tumorigenesis and develop new methods of eliminating cancer cells. With extensive experience in embryonic stem cells (ESCs), mesenchymal stromal/stem cells (MSCs), and osteosarcoma (OS), we collaborate with intramural and extramural colleagues to study breast cancer. However, we have recently expanded our research to include transcription factors (e.g., RUNXs, CBFB) that interact with p53. To date, we have primarily focused on studying the tumor suppressor p53, also known as the guardian of the genome. Specifically, my laboratory investigates the biological functions of transcription factors that play critical roles in both stem cell and cancer biology. ![]() My research interest centers around understanding gene expression regulation in both stem cells and cancer cells. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |